Introduction: Considering the influence of Brain/Behavioral systems on Coping Skills with stress, the present study aimed at investigating the relationship of the Brain/Behavioral systems with Coping Skills with stress and its role in the mental health of students.

Methods: This study is descriptive (survey). For this purpose, 300 girl students of Mathematics- Physics Field (zone 4) Tabriz in Ranging in age from 16 to 18 years to the Cluster sampling - were selected. Data collection tools included Carver & White’s   BAS / BIS questionnaire, Falkmn & Lazarus’s Coping Skills Inventory and Goldberg & Hillier’s General Health Questionnaire. To test the research hypotheses, Pearson correlation and to investigate the role of Brain/Behavioral systems and Coping Skills in mental health, the regression analysis were used.

Results: Total score of mental health and its components with Problem solving coping style and activation brain system Negative relationship and Emotional coping style and Behavior Inhibition brain System is a significant positive relationship. As well as Problem solving coping style with activation brain system positive relationship and a significant Negative correlation with behavioral inhibition brain system. Emotional coping style with activation brain system Negative correlation and a significant positive correlation with behavioral inhibition brain system.

Conclusion: The results showed that students' mental health in the physical, psychological and social impact of different sensitivity of Brain- Behavioral systems and Individuals coping strategies to daily stress is placed.