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Examining the relationship between Glucose-6-phosphate dehydrogenase deficiency and neonatal hyperbilirubinemia admitted to hospital Imam Sajad Yasouj
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F Mahmoudi   , A Mobaraki , Z Mahmoudi , F Jahanpour |
| , Fatemeh.mahmoodii66@yahoo.com |
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Abstract: (15841 Views) |
Introduction:G6PD is One of enzyme is essential for red blood cell metabolism. Jaundice is caused by a deficiency of the g6pd enzyme appears in the form of acute hemolytic anemia with increased indirect bilirubin and sometimes so severe hemolysis protests that babies require blood transfusions. If the absence of appropriate action does not create a neurological complications (kernicterus) . The aim in this study is Examining the relationship of G6PD deficiency in newborn infants with jaundice admitted sector, also study communication between This deficiency with risk factors .
Method: This study was descriptive analysis . samples in this study was 596 infants in the Neonatal jaundice to Imam Sajad hospital at 6 months were admitted. Was considered Deficient g6pd infants (61 cases group)and rest infants (535 cases) had Babies with jaundice without deficient activity of G6PD . Were extracted G6PD, CBC, reticulocyte count, the medical records and direct Coombs than the results were statistically analyzed with spss version 19.
Results : The overall prevalence of G6PD deficiency in neonates with hyperbili was 10.23%, of which 63.9% were male and 36.1% female babies. The mean total bilirubin in the study group and the control group was 18.23, 15.61 mg dL showed a significant difference (p <0.05). In addition was performed in 5(6.19%) cases exchange transfusion. The mean hematocrit, hemoglobin, reticulocyte count in the case and control groups, showed no significant difference (p> 0.05).
Conclusion: Given the high prevalence of deficiency of the enzyme and its relation to other studies with jaundice and neurological complications, is required screening for all newborns after birth and Infants at high risk, turned quickly treated and prevent hemolysis attacks in childhood. |
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| Keywords: Glucose-6-phosphate dehydrogenises, jaundice Neonatal |
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Full-Text [PDF 714 kb]
(2287 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/02/24 | Accepted: 2015/05/26 | Published: 2015/09/11
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