Introduction : Asthma is a chronic disease reduce the level of quality of life for children. The ultimate goal of Health science is increasing the quality of life. Therefore, this study aimed to investigate the effect of self-care program on quality of life of school-age children with asthma.

Methods: This study is a quasi-experimental study. The sample were calculated 60 (test group and control group). Samples were selected from Children's Hospital of Babol city. Self care program designed in 7 steps include: Assessment and Recognition, determine the level of behavior change based on a behavior change model, setting staging table for behavior changing, Scoping and planning, Preparation necessary requirements to run the program, run the program as a group and final self care evaluation in test group And after a month quality of life of the children in both groups was measured.

Results: The mean score of self-care before the intervention and after the intervention are 107.23 and 127.3, standard deviation (SD) before the intervention and after the intervention are 14.48 and 11.94.  Before the intervention, no significant difference was observed in self-care and quality of life of the experimental group s and control group(p>0/05), but this difference was statistically significant after the intervention(p<0/050).

Conclusion: The results of this study showed that self-care programs are effective to improve the quality of life of school-age children with asthma.