Introduction: Burnout is a common problem among medical and health staffs; pediatrics and NICU nurses, according to the more stressors which have to tolerate, may be at higher risk. Nurse’s burnout not only affects negatively patient’s care, but also can harm their physical and mental and general health as well as the quality of work life. The aim of this study was determining the relation between burnout and quality of work life in pediatric and NICU nurses.

Methods: In this descriptive and correlation study, 76 nurses Employed in the pediatrics/NICU wards of Isfahan Medical University hospitals in 2014 were selected. The data gather by Maslach Burnout and Quality of work Life, and was completed by the samples. They were analyzed by SPSS₂₀ and Student’s independent t-test, and Pearson correlation test.

Results: The results showed that the mean score of burnout within the frequency and intensity of the "personal performance" respectively74.2±20.3 and 59.7±20.6, And in terms of frequency and intensity of the "conflict" 47.4±22.1 and 44.8±20.5 was obtained, that the highest average score of burnout within the first personal performance and conflict.(p<0/05)

Conclusion: Due to the high average burnout score in the area of personal performance, and ultimately have a direct impact on the quality of work life pediatric and NICU nurses, therefore The managers and directors of nursing by creating a good working environment and job protection of complications, which can reduce productivity and prevent low quality care.