Introduction: Thalassemia patients in the path of life, interferes. While the complexity and difficulty of increasing self-efficacy will decrease. This study was designed to determine social, emotional and academic self efficacy in 7- 12 aged children with major thalassemia in mashhad (2013).
Method: This cross sectional descriptive study. The sample include 60 child with major thalassemia. To gather data, the standard Muris self efficacy was used. Content validity was confirmed and its reliability was 0.72
Results: self efficacy with Mean and Standard deviation 75.1±6.9, Social 23.9±4.6 and emotional 19.9±2.3 were modrate.  Academic self efficacy with mean and standard deviation 31.1±3.9 was high.
Conclusion: The results of this study showed these children with major thalassemia had low self-efficacy. In order to improve the quality of life for children with thalassemia and social success improving believe of their abilities is necessary