Background and objective: asthma is one of the most common chronic diseases in children. It includes the most reasons of the school absence in children and adolescent age group and is one of the main reasons of children's reference to emergencies and hospitalization. This disease has many consequences on physical and mental dimensions and social growth and children's development and the economical cost resulting from it's phathogenesis, is high. So this study has been done with the aim of investgating the effect of of self care program education on quality of life of school aged children suffering from asthma. Methods: In this randomized clinical trial, 88 children suffering from asthma were incorporated in to the study as randomly sampling in two education group (n=44) and control (n=44). first the quality of the children's life in both groups was earned and registered questionnaire PAQLQ. Then self-caring program education including getting familiar with the patient, how to use the medicines, activities and exercise and soon were performed during 4-5, 30-45 minutes sessions for the children in education group. It was while no intervention was done in control group. Immediately and 8 weeks after intervention again, the mentioned questionnaire was completed by children. The data were analyzed using statistical tests, Results: the findings of this investigation showed, there is a meaningful statistical difference between the score of children’s quality of life in two groups. So that, in education group it has arrived from 48.6 ± 6.2 to 57.9 ± 5.6 (p=0.00). While, no statistical meaningful difference was seen in control group. Discussion and conclusion: the results of this study and previews studies show that the education intervention and improving the ability of self-caring in children suffering from asthma, lead to increasing their quality of life. Therefore, according to the high prevalence of this disease in the country, and economical and social load resulting from it, it can be considered in scheduling for this age group of self- caring education to improve the turnover and reinforcing the self-control.