Introduction: disabled children cause many psychological problems in family members especially on mother. Because the importance of mental health of mothers in family and society this study investigated the effectiveness of hope-oriented group therapy on life meaning and resilience in mothers with physical-motor disabled children.
Method:This research is a quasi-experimental study with pre and post-tests. The 24 mothers with physical-motor children were selected from Aria Rehabilitation Clinic, Omid and Behesht training center and Welfare Organization of Save city Markazi province. The participants were allocated to two matched groups based on their pre-test scores. They were assigned randomly to the control and experimental groups. Statistical analysis was conducted by using the independent t-test and analysis of variance. The research instrument were the Connor- Davidson Resiliency scale (CD-RISC) and Frankl’s life meaning Questionnaire.
Results: The results of the co-variety (ANCOVA) showed that there is a significantly difference between training help-oriented group therapy and resilience (p≤0.0002). while, hope therapy has not significantly influence on life meaning in control and experimental groups .(p≥0/635)
 Conclusion: The results indicate that hope therapy improve the positive psychology factors such as resilience and hope in mothers with disability children.